Arsenite‐induced mitotic death is distinct from both nocodazole and Taxol
نویسندگان
چکیده
منابع مشابه
Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.
Taxanes are powerful chemotherapy agents that target the microtubule cytoskeleton, leading to mitotic arrest and cell death; however, their clinical efficacy has been hampered due to the development of drug resistance. Therefore, other proteins involved in spindle assembly are being examined as potential targets for anticancer therapy. The mitotic kinesin, Eg5 is critical for proper spindle ass...
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In this paper we explore detection and tracking of astral microtubules, a sub-population of microtubules which only exists during and immediately before mitosis and aids in the spindle orientation by connecting it to the cell cortex. Its analysis can be useful to determine the presence of certain diseases, such as brain pathologies and cancer. The proposed algorithm focuses on overcoming the pr...
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A range of DNA-damaging agents has been shown to increase cellular levels of the nuclear phosphoprotein p53 and to induce p53-dependent processes. We examined the ability of three microtubule-active agents, taxol, vinblastine, and nocodazole, to increase p53 levels and activate p53-dependent processes. When tested using a p53 DNA-binding assay, all three agents induced p53 in a dose-dependent m...
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Caspase-free mitot ic death O n page 283, Niikura et al. document a new way for abnormal cells to kill themselves. The mechanism might weed out potentially cancerous cells in which the spindle checkpoint has malfunctioned. Before progressing through mitosis, cells verify that the microtubules of the spindle apparatus are properly attached to the chromosomes. If they aren’t, the spindle checkpoi...
متن کاملMitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.
Paclitaxel at low concentrations (10 nM for 20 h) induces approximately 90% mitotic block at the metaphase/anaphase transition in HeLa cells, apparently by suppressing dynamics of spindle microtubules (M. A. Jordan et al., Proc. Natl. Acad. Sci. USA, 90: 9552-9556, 1993). It is not known, however, whether inhibition of mitosis by such low paclitaxel concentrations results in cell death. In the ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a806-a